Causes triggering psoriasis. Triggering factors. The most common triggering factors are stress, trauma on the skin, streptococcal infections (can trigger guttate psoriasis), drugs (trigger psoriasis or make it worse) and suspension of some drugs. The exact cause of psoriasis is unknown, but it is determined that it is not a skin infection; but an inflammatory disease.
The exact cause of psoriasis is unknown, but it is determined that it is not a skin infection; but an inflammatory and chronic disease of unknown etiology, with immunogenetic basis and where multiple triggers are involved.
The research suggests that psoriasis may be caused by an immune system problem. On the basis of the results of such research, psoriasis was gradually referred to as immune-mediated disease, a category that describes any condition caused by the immune system attacking its own body tissue.
Most of the cells divide and replace about once a month (every 28-30 days).
When new cells emerge, the old skin cells on the surface die and disperse.
In the presence of psoriasis, this process does not work precisely. Instead of reproducing each month, the skin cells of the affected areas regenerate every 3-6 days, increasing enormously. The high number of new cells that emerge quickly accumulates above and immediately below the surface of the skin, causing increasingly lesions and scaly patches. In its most common form (plaque psoriasis), the scales on the skin surface break easily, creating white or silver patches. The cells below the surface stick together, forming tender and red lesions prone to bleeding. The skin inflammatory condition is also due to the increase in the number of inflamed cells (white blood cells).
Adapted from: Nickoloff BJ, Nestle FO. J Clin Invest. 2004 Jun; 113 (12): 1664-75.
The tendency to develop psoriasis can be hereditary.
Researchers suspect that psoriasis is caused by a combination of genetic and environmental factors.
It's true that someone may suffer from psoriasis hereditarily, but it is equally true that psoriasis develops only when there is a factor such as an infection, taking certain medications, trauma or stress.
Most of the people manifests the first eruption between 15 and 35 years, although psoriasis may appear at any age, even after 80 years old.
The most common triggering factors are:
Stress: It has been shown that stress can trigger psoriasis or aggravate it.
Trauma on the skin: When psoriasis appears in areas of traumatized skin (sunburn, scratches, vaccinations) it is recognized as the phenomenon of Koebner .
Infectious factors: It is the most known triggering factor. The association with a group A beta hemolytic streptococcal infection is significant in patients who have a first outbreak of guttate psoriasis.
2/3 of the cases in children are associated with upper tract infections, streptococcal pharyngitis and occasionally perianal dermatitis.
Other germs that could act as triggers of an outbreak are: Staphylococcus aureus, Candida albicans in the folds, Pityrosporum ovale in scalp, HIV infection can lead to severe psoriasis and refractory to the usual treatment.
Drugs: Some drugs have been shown to trigger psoriasis or make it worse in some cases. Such as:
• Lithium pharmaceuticals for psychiatric use.
• Antimalarial drugs (quinacrine, chloroquine and hydroxychloroquine).
• Some medications for high blood pressure such as beta blockers (atenol, propranolol), angiotensin inhibitors (captopril, enalapril, lisinopril)
• Heart drugs based on quinidine.
• Some medications for arthritis, as the NSAIDs.
• The suspension of some steroid drugs (corticosteroids)
Weather factors, geography and ethnicity:
Weather plays a role in the risk of contracting the disease, the disease manifests itself earlier and more frequently in cold weathers and improves in hot weathers.
Psoriasis is not common in Native American Indians or their descendants in North and South America.
Psoriasis is associated more frequently than would be expected from the general population, with certain alterations such as:
_ Alterations of the cardiovascular system: hypertension, arteriosclerosis, myocardial infarction.
_ Endocrine and metabolic factors: obesity, dyslipidemia, diabetes, hypocalcemia, menopause.
_ Several chronic inflammatory diseases (rheumatoid arthritis), severe joint disability
_ Tobacco addiction and alcoholism.
_ Crohn's disease.
_ Depression and suicidal ideas.
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