Psoriasis and physical trauma. It appears in places where the skin receives a traumatic damage. Under the name of Koebner phenomenon, it increases in patients who suffer from active psoriasis and is responsible for the appearance of the lesions around two weeks after the triggering event.
Psoriasis appears in places where the skin receives a traumatic damage. Under the name of Koebner phenomenon, it increases in patients who suffer from active psoriasis and is responsible for the appearance of the lesions around two weeks after the triggering event. The hypotheses, that try to explain this phenomenon, support that when cutaneous damage occurs, the cytosines involved in the pathogenesis of the disease are released. The lesion is described as any change of the skin such as the diaper rash, rubbed, scratches and / or lacerations, surgical incisions, etc. This phenomenon can have also a respond to sunburns, radiation and injuries by irritating or caustic chemical agents.
Psoriasis and infections:
Infections are recognized as the triggering factor for the onset or exacerbation of psoriasis. What is meant by infection is a pathological reaction of any organism to the penetration and multiplication of microorganisms (viruses, bacteria, mycetes, protozoans, metazoans).
The 54% of children living with psoriasis reports an exacerbation of the disease over a period of 2 to 3 weeks right after an upper respiratory tract infection resulting from a group A beta-hemolytic streptococcus. This figure refers to 26% of patients with acute gutatte psoriasis and 16% of patients with chronic psoriasis. Among the microorganisms that could trigger it we have staphylococcus aureus, candida albicans in folds and pytirosporum ovale in the scalp.
The rapid onset of acute eruptive psoriasis as well as exacerbations in patients with a history of chronic stable plaque psoriasis suggests the first clinical manifestation of human immunodeficiency virus type 1 (HIV-1) infection. This viral Infection along with immunosuppression can lead to severe psoriasis resistant to usual treatment.
Psoriasis, Toxic Habits and Hygiene:
Multiple authors have analyzed the relation among alcohol, cigarettes and psoriasis. The first one seems to have a great influence on the increase of the disease, especially in men, whereas the association between smoking and psoriasis is stronger in women.
Regarding daily hygiene, it is important to avoid aggressive soaps and choose soaps with moisturizing and soothing properties, as well as to preferably use a natural and delicate sea sponge instead of a synthetic one that irritates and damages the skin during the first months of infants’ life.
Remember that after the shower or bath the pores are more dilated and the skin is more permeable to topical treatments so that it is the right time for applying creams and lotions.
Psoriasis and tumors:
Some studies have reported a higher incidence of malignant tumors in patients with psoriasis. This result could be related to the treatments received or to the disease itself, due to the immunological basis of the pathogenesis of psoriasis. A greater relationship with lymphomas has been considered, especially Hodgkin's disease and variants of cutaneous T-cell lymphoma (CTCL) such as mycosis fungoides and Sézary's syndrome.
The use of cyclosporine and methotrexate has been associated with the development of lymphoma. Biological therapies, by selectively acting on specific components of the immune system, could also increase this risk.
Other studies have shown an increased risk of solid malignancies including female oral cavity, esophagus, pharynx, larynx, liver, pancreas, lungs, bladder, kidneys, breast and colon cancer and male genital organs cancer except prostate.
It is recommended that patients using these treatments should frequently examine skin lesions through periodic checkups performed by the physician / dermatologist to avoid the slightest possibility of melanoma or other skin cancer and thus, live a healthy life.
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