Psoriasis and the genes Psoriasis and genetic factors There are many aspects related to psoriasis outbreaks: environmental, traumatic, infectious, psychological and others related to lifestyle. On the basis the most important of all, the genetic one.
Psoriasis is a skin disorder that stars showing with the appearance of thickened and scaly spots having a size that ranges from a few millimeters to a few centimeters in diameter. It is an inflammatory skin disease that is often associated with metabolic and/or cardiovascular disorders, as well as osteoarticular disorders, such as psoriatic arthritis, and is considered a disease that “ not only affects the skin”.
There are many aspects that have to do with its appearance and exacerbation, such as: environmental, traumatic, infectious, psychological factors and others related to lifestyle like the ingestion of alcoholic beverages and/or smoking. For this reason, it is defined as a multifactorial pathology, because it needs a combination of more factors to show up.
On the basis of these factors we find the most important of all, the genetic one, since the disease shows itself more frequently in those people with genetic predisposition to suffer it.
It is often thought that if a child has the mother and/or father suffering from psoriasis he will surely have it.
This is not quite accurate. In fact the difference between genetic or familial pathology and hereditary pathology should be specified.
Genetic or familial factors are genes that are transmitted from parents to children whose characteristics, when interacting with other factors (triggers, can lead to the onset of pathology, although this depends on its association.
The hereditary factor, however, follows precise rules of transmission from one generation to another, exactly under the same criteria of how the colors of the eyes or the blood group are transmitted.
However, it should be noted that the onset of psoriasis is not always associated with a genetic cause. The reason is the combination of several risk factors such as: enzymes disorders, lipid metabolism, amino acid metabolism, viruses’ multiplication, streptococcal infections, among others.
In short, a hereditary disease always has a genetic basis, while a genetic disease is not necessarily hereditary.
Therefore, it is clear that the genetic predisposition to psoriasis consists of a particularly complex polygenic model that, for now, confirms there are no genetic markers to be analyzed to determine if a person may or may not develop psoriasis during his lifetime. But it is important, if you think you have a predisposition (or if you know other cases of first-degree relatives) to adopt preventive measures by paying more attention to everyday actions, from clothing to proper hydration, from food to Sport, because thanks to these small details, the strong exacerbations of the disease can be under control.
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